ABSTRACT
Introduction: Parkinson’s disease (PD) is one of the chronicneurodegenerative disorder and is the most common cause ofparkinsonism, which is a syndrome manifested by rest tremor,rigidity, bradykinesia, and postural instability. Diabeteswhether is a risk factor for developing PD is a question oftenraised for many years and to date there are conflicting data onassociation of diabetes and Parkinson’s disease. Study aimedto study the effect of glycemic status on Idiopathic Parkinson’sdisease (PD) and to identify the modifiable and non modifiablerisk factors in idiopathic Parkinson’s disease (PD).Material and methods: Consecutive patients with adiagnosis of idiopathic parkinson’s disease(PD) satisfyingUK Parkinson’s disease society brain bank clinical diagnosticcriteria attending the department of neurology during theperiod January 2019 to December 2019 were included in thestudy. Study design was a cross sectional, observational study.Results: Total of 70 patients were enrolled in the study. Tremorwas the most common motor symptom. 53.3% of subjects hadone or the other non motor symptoms. Diabetes was presentin 38.6% of subjects. Mean FBS among the cases was 112.36% of the subjects had poor control of diabetes based ontheir HbA1C values (HbA1C >7). There was statisticallysignificant relation between glycemic control and clinicalstage of PD with a P value <0.05.Conclusion: Prevalence of diabetes in PD is significantlyhigher compared to general population statistics. PD patientshad favourable lipid parameters. Poor glycemic control amongPD with diabetes had statistically significant relationship withclinical stage.
ABSTRACT
Introduction: Febrile seizures are the commonest epilepticdisorder in children aged till 5 years. In some children febrileseizure tend to occur after the age of 6 years, although wellreported phenomenon the Clinical and EEG features is lessclear. Study aimed to analyse the Clinical and EEG profile infebrile seizures in Children aged between 6 to 12 years.Material and methods: All patients - Typical and AtypicalFebrile seizures in the age group 6-12 years attending thetertiary referral centre in eastern Tamilnadu were included.Patients with structural lesions, CNS infections and thosewith previous afebrile seizures were excluded. 30 Subjectsfulfilling the criteria were included in the study. A carefulneurological examination with appropriate laboratory tests,imaging and EEG was performed.Results: Out of 30 children 22 were in the 6-9 age group andrest in 10-12 age group.12 girls and 18 boys comprised thestudy group. 22 subjects (73.3%) presented with GTCS, 3with focal seizures and 5 with febrile status. Family historyof febrile seizure was present in 40% and family historyof epilepsy in 26.6%. 4 children (13.3%) had behaviouralproblem and 33% had learning difficulty. EEG was abnormalin 60% of study population. Hyponatremia was found in36.7% of the subjects. Imaging abnormality was noted in 3subjects.Conclusion: Abnormal EEG had significant positiveassociation with learning difficulty (p<0.05). Hyponatremiahad significant association with occurrence of febrile status.